BMP

BMPs are TGF-β superfamily signaling proteins first defined by bone-inducing activity and now linked to embryogenesis, organ development, and adult tissue homeostasis^[1]^[2]. Mechanistically, BMP ligands activate type I/type II receptor complexes that phosphorylate SMAD1/5/8, driving context-dependent transcriptional programs^[3]. In limb models, BMP2, BMP4, and BMP7 participate in limb patterning and skeletogenesis, providing a practical developmental framework for BMP pathway research^[4]. Compared with related isoforms, BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis, while BMP6 and BMP9 show robust orthotopic bone-forming activity in adenoviral mouse models^[5]^[6]. For experimental applications, dorsomorphin inhibits BMP type I receptors ALK2, ALK3, and ALK6, whereas LDN-193189 reduces heterotopic ossification by inhibiting BMP type I receptor activity^[7]^[8].

References:

[1]. Wozney JM, et al. Novel regulators of bone formation: molecular clones and activities. Science. 1988 Dec 16;242(4885):1528-34. [Content Brief]

[2]. Wang RN, et al. Bone Morphogenetic Protein (BMP) signaling in development and human diseases. Genes Dis. 2014 Sep;1(1):87-105. [Content Brief]

[3]. Katagiri T, et al. Bone Morphogenetic Proteins. Cold Spring Harb Perspect Biol. 2016 Jun 1;8(6):a021899. [Content Brief]

[4]. Bandyopadhyay A, et al. Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis. PLoS Genet. 2006 Dec;2(12):e216. [Content Brief]

[5]. Kim HS, et al. BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis. Elife. 2019 Sep 30;8:e48872. [Content Brief]

[6]. Kang Q, et al. Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. Gene Ther. 2004 Sep;11(17):1312-20. [Content Brief]

[7]. Yu PB, et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol. 2008 Jan;4(1):33-41. [Content Brief]

[8]. Yu PB, et al. BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med. 2008 Dec;14(12):1363-9. [Content Brief]

BMP Inhibitor (1)

BMP Related Products (1):

By Type:	Selective (1)

Cat. No.	Product Name	Effect	Purity

HY-12273G

DMH-1 (GMP)	Inhibitor
DMH-1 (GMP) is GMP grade DMH-1 (HY-12273). DMH-1 (GMP) is a selective BMP inhibitor. DMH-1 (GMP) upregulates the expression of SOX1. DMH-1 (GMP) increases cardiomyocyte progenitor cells and promotes the differentiation of mouse embryonic stem cells into cardiomyocytes. DMH-1 (GMP) induces the differentiation of hiPSC-derived neural progenitor cells into β3-tubulin-positive neurons.

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